A Safety and Efficacy Study of Setipiprant Tablets in Androgenetic Alopecia in Males

A Safety and Efficacy Study of Setipiprant Tablets in Androgenetic Alopecia in Males

Den nyaste forskningen relaterad till håravfall
User avatar
whyatt
Posts: 9487
Joined: 20 Jul 2007, 13:24

13 May 2019, 12:05

Allergan vill nog väldigt gärna på allvar få ut en tablett på marknaden, men är Setipiprant tillräckligt säker och effektiv long term?

https://clinicaltrials.gov/ct2/show/study/NCT02781311

Change From Baseline in Target Area Hair Count (TAHC) at Week 24 [ Time Frame: Baseline (Day 1) to Week 24 ]
TAHC was measured using digital imaging analysis and was reported in terminal hairs/centimeters square (cm^2). TAHC is a standardized objective quantification of the number of hairs within a prespecified target area of the scalp at different timepoints, using macrophotography digital images. The total number of terminal hairs (hair width ≥ 30 μm) was calculated from macrophotographs. The target area used to count TAHC was a 1 cm^2 circular area of clipped hair (length approximately 1 mm) located at the anterior leading edge of the vertex thinning area of the scalp and centered with a semi-permanent microdot tattoo to ensure the same target area was reproduced at each visit. A positive change from Baseline indicated improvement (increase in the number of terminal hairs). Missing data are imputed up to Week 24 using last observation carried forward (LOCF) method.

Subject Self-Assessment (SSA) Score in Hair Growth at Week 24 [ Time Frame: Week 24 ]
The SSA consisted of a single-item measure that assesses each participant's perception of change in scalp hair growth. The participant used a standardized global photograph of his scalp taken at the Screening visit presented side by side with a standardized global photograph taken at the postbaseline visit to give a comparative score. The photographs were presented in a blinded and randomized manner to avoid influencing the participant, and response options were on a 7-point ordinal scale (where, ‐3=Greatly decreased, ‐2=Moderately decreased, ‐1=Slightly decreased, 0=No change, +1=Slightly increased, +2=Moderately increased and +3=Greatly increased). The higher the mean SSA value, the more the perception of hair growth from baseline. Missing data are imputed up to Week 24 using LOCF method.
Hår: Omfattande program för 2019. Mer info kommer senast i maj
Kost: Mestadels LCHF (med lågt intag av växtbaserade livsmedel)
Träning: Gym 4-5 ggr/vecka & Intervall i backe 1-2 ggr/vecka
Psyke: Solarium-D3-Ashwagandha-Spikmatta-Mindfulness
Skriv inlägg